Microprocessor of microRNAs: regulation and potential for therapeutic intervention
نویسندگان
چکیده
منابع مشابه
micrornas and asthma regulation.
micrornas participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of micrornas in the pathogenesis of asthma. a review of the english medical literatures was conducted by searching pubmed for studies concerning asthma and micrornas. the results of the present study indicate that micrornas play important roles in regulating asthma immune res...
متن کاملTelomerase and its potential for therapeutic intervention.
Telomerase and telomeres are attractive targets for anticancer therapy. This is supported by the fact that the majority of human cancers express the enzyme telomerase which is essential to maintain their telomere length and thus, to ensure indefinite cell proliferation--a hallmark of cancer. Tumours have relatively shorter telomeres compared to normal cell types, opening the possibility that hu...
متن کاملMicroRNAs in Osteoclastogenesis and Function: Potential Therapeutic Targets for Osteoporosis
Abnormal osteoclast formation and resorption play a fundamental role in osteoporosis pathogenesis. Over the past two decades, much progress has been made to target osteoclasts. The existing therapeutic drugs include bisphosphonates, hormone replacement therapy, selective estrogen receptor modulators, calcitonin and receptor activator of nuclear factor NF-κB ligand (RANKL) inhibitor (denosumab),...
متن کاملPrion degradation pathways: Potential for therapeutic intervention
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be developed, strategies aimed at stimulating the degradation of PrP(Sc) have shown efficacy in experimental models of prion disease. Here, we de...
متن کاملThe therapeutic potential of microRNAs in heart and vascular diseases
The potential use of microRNAs (miRNAs) to design novel therapeutic approaches in cardiovascular diseases (CVD) has emerged as a promising strategy. miRNAs are small, noncoding RNAs that regulate gene expression epigenetically. Increasing evidence suggests that miRNAs operate as regulatory networks that target functionally related genes in physiological and pathological conditions. This propert...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2010
ISSN: 1476-4598
DOI: 10.1186/1476-4598-9-134